Electrochemical Response of Redox Amino Acid Encoded Fluorescence Protein for Hydroxychloroquine SensingArticle Published on 2023-02-012023-07-10 Journal: Applied biochemistry and biotechnology [Category] COVID19(2023년), [키워드] Bio-redox protein biosensor chitosan electron transfer Hydroxychloroquine L-3,4-dihydroxyphenylalanine. [DOI] 10.1007/s12010-022-04142-w PMC 바로가기
Potential interactions between antineoplastic agents and medicines used to treat Covid-19Article Published on 2022-12-012022-11-15 Journal: Journal of Oncology Pharmacy Practice [Category] 치료제, [키워드] accounted Affect antineoplastic agents antineoplastic drug Baricitinib benefit Cancer Chloroquine Combination conducted COVID-19 disease drug drug combinations drug-drug interaction Drug-drug interactions Drug–drug interactions drug–drug interactions. Health Hydroxychloroquine identify Interaction interaction effect interactions involved Lexicomp Medicine Modification outcomes Patient Patients with cancer pharmacokinetic pharmacological intervention plasma concentration Potential professional risk severity therapeutic treat Treatment tyrosine kinase inhibitor was increased [DOI] 10.1177/10781552211040494 PMC 바로가기
Safety profile of hydroxychloroquine used off-label for the treatment of patients with COVID-19: A descriptive study based on EudraVigilance dataArticle Published on 2022-12-012023-07-09 Journal: Fundamental & clinical pharmacology [Category] COVID19(2023년), [키워드] benefit-risk balance COVID-19 Hydroxychloroquine off-label Safety. [DOI] 10.1111/fcp.12797 PMC 바로가기
Additively manufactured electrodes for the electrochemical detection of hydroxychloroquineArticle Published on 2022-12-012022-11-16 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation addition Additive Additive manufacturing Analysis applicability aquatic environments Cell Complete Concentration confidence level contaminant coronavirus demonstrated Electroanalysis FDM Fused filament fabrication HCQ hospitalized patient Hydroxychloroquine limit of detection linear organization pandemic Precision SARS-CoV-2 sensors. shown Tablet tap Treatment [DOI] 10.1016/j.talanta.2022.123727 PMC 바로가기
Spectrofluorimetric quantitative analysis of favipiravir, remdesivir and hydroxychloroquine in spiked human plasmaArticle Published on 2022-11-152023-07-10 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] COVID19(2023년), [키워드] COVID-19 Favipiravir Hydroxychloroquine Remdesivir Synchronous fluorescence spectroscopy. [DOI] 10.1016/j.saa.2022.121625 PMC 바로가기
The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidenceArticle Published on 2022-10-182022-11-16 Journal: History and philosophy of the life sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] agency Analysis applied approval clinical trial Compound conducted COVID COVID-19 EBM+ effective Efficacy Evidence example Excessive hypothesis testing explain false-positive result False-positive results favor Hydroxychloroquine Hypothesis less Mechanistic evidence Medical nihilism. Medicine ongoing trial other diseases Perspective risk second tested therapeutic therapy Treatment treatment for COVID-19 Trial [DOI] 10.1007/s40656-022-00532-9 PMC 바로가기
Kinetics of Drug Molecule Interactions with a Newly Developed Nano-Gold-Modified Spike Protein Electrochemical Receptor SensorArticle Published on 2022-10-172022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification antiviral drug Chloroquine compounds Concentration correlated COVID-19 Detection sensitivity Developed docking drug drug target drugs electrochemical receptor biosensor exhibit Gln group Hydrogen bond Hydroxychloroquine Interaction investigated kinetic Kinetics limit of detection linear linkage allosterism molecule pandemic Protein provide receptor reported Research residue SARS-CoV-2 sensor Seven spike Spike protein spike protein. the SARS-CoV-2 the spike protein Treatment was used WHO World Health Organization [DOI] 10.3390/bios12100888 PMC 바로가기
Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2Article Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro Antiviral Antiviral compound binding binding affinity binding energy calculated catalytic Characteristics complex Compound Corona COVID-19 COVID19 database determine docked docking drug examined explicit solvent group HCQ Hydroxychloroquine identify inhibitor initial Interaction investigated medium molecular pharmacophore Pharmacophore screening physiological Poisson produced protease Protein RdRP RdRp protein residue RNA-dependent RNA polymerase SARS-CoV2 SARS-CoV2 inhibitor. screened Spike protein therapeutic therapy trajectory treat treated [DOI] 10.1007/s11030-021-10358-5 PMC 바로가기
Using EHR data to identify coronavirus infections in hospitalized patients: Impact of case definitions on disease surveillanceArticle Published on 2022-10-012022-11-15 Journal: International journal of medical informatics [Category] COVID19(2023년), SARS, 치료제, [키워드] age and sex anti-IL6 Antiviral Case definition Characteristics Clinical diagnosis clinically cohort characteristics Complication coronavirus disease Coronavirus infection COVID COVID-19 diagnosed Disease surveillance EHR data Electronic health records. evaluate evaluated Health health system Hospitalized Hydroxychloroquine identify Impact Inpatient lab Laboratory laboratory confirmation Laboratory test laboratory-confirmed Myocardial infarction outcome outcomes overall mortality Patient patients hospitalized positive receive Record required SARS-CoV-2 The United States therapy with COVID-19 [DOI] 10.1016/j.ijmedinf.2022.104842 PMC 바로가기
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patientsShort communication Published on 2022-10-012022-10-30 Journal: Contemporary Clinical Trials Communications [Category] COVID-19, 임상, 치료법, [키워드] AE/SAE Analysis Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) Arm baseline controls COVID-19 COVID-19 patients double-blinded Efficacy and safety Enrollment Final hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine IMPROVE Lopinavir-ritonavir losartan Mortality MOST objective outcome pandemic parameter Patient Placebo placebo-controlled platform primary endpoint Randomized randomized clinical trial Randomized clinical trial (RCT) RCT Result SARS-CoV-2 score slow standard care the mean Treatment [DOI] 10.1016/j.conctc.2022.100968 [Article Type] Short communication